HMBS and leukemia: To validate the function of SETD1A target genes (COX15, HMBS, UROS, RRNAD1, NUDT18, GSTZ1, HINT2, and COX18) in leukemia cells, we performed a CRISPR-based competitive cell proliferation assay in doxycycline-inducible Cas9-expressing MOLM-13 leukemia cells (Figures 3A and S3A).