SETD1A is frequently mutated in the brain of patients with neurogenerative disease,32,33 and the heterozygous mutation in mice recapitulates the schizophrenia-related phenotypes.4,6 These mutations are not only observed at the enzymatic domain but also at the FLOS domain.32 Understanding the molecular mechanisms behind the SETD1A-dependent heme biosynthesis pathway will offer insight into neuronal disorders and other diseases. The gene discussed is SETD1A; the disease is schizophrenia.