The DKK protein family is traditionally known to regulateWNT signaling, but all four members are associated with the modulationof the antitumor immune response as well (Table 1).101−103 We found that DKK3, but notDKK4, was able to negatively affect the killing capacity of NK cellsfor CRC cells, but that neither was able to decrease the activityof CTLs in a patient-derived colon cancer model. The gene discussed is DKK3; the disease is colonic neoplasm.