Furthermore, although the tested CTLsare reactive to the tumor organoids, as shown by the strong decreasein live cells after the addition of CTLs (no CTL vs 0 conditions),no effects of the DKKs on their killing capacity could be observed.There are several potential explanations for the discrepancy in theeffect of DKK3 on the killing capacity of immune cells in the HT29and PDO experiments. This evidence concerns the gene DKK3 and neoplasm.