Cannabinoid receptor agonists, such as anandamide and noladin, have been shown to protect against neurotoxicity caused by beta-amyloid in differentiated neuronal cells through binding to the CB1 receptor and activation of the MAPK pathway.(112) The increased concentration of 2- arachidonoylglycerol through the pharmacological inhibition of monoacylglycerol lipase robustly suppressed the production and accumulation of beta-amyloid plaques associated with decreased expression of the enzyme that participates in the synthesis of beta-amyloid in model mice with AD. Here, MGLL is linked to Alzheimer disease.