CREB1 and Alzheimer disease: Glycogen synthase kinase 3 proved to be a beneficial biomarker for AD diagnosis through the GSK3β assay.(85) In addition, several studies have already reported an interaction between GSK3 and oxidative stress in neuroinflammation.(86) Moreover, GSK3 potentiates the process of apoptosis and cell death by regulating the transcription of various factors, such as heat shock factor-1 (HSF-1), cyclic-AMP response element-binding protein (CREB), and nuclear factor Kappa B (NF-κB).