The most frequent globular forms of acetylcholinesterase in the brain as a whole are G1 and G4, but there is a reduction in the levels of the G4 form in AD, suggesting the G1 form of acetylcholinesterase is the most viable therapeutic target.(40) However, no studies have proved these anticholinesterases promote regression of the disease; they only bring temporary relief of symptoms, especially in the early stages.(41). The gene discussed is ACHE; the disease is Alzheimer disease.