The cognitive deficits presented by AD patients correlate with a cerebral disorder in sensitive areas of the brain, mainly in the frontal cortex and the hippocampus, which are rich in CB1.(109) Correlation analyses based on histological sections of post–mortem brain tissues from patients with confirmed AD indicated low levels of CB1 when compared to control groups with corresponding age.(110). This evidence concerns the gene CNR1 and Alzheimer disease.