NIPBL and Cornelia de Lange syndrome: In contrast, Nipbl up-regulated genes (table S13) sort intogeneric pathways involved in epigenetics (e.g., chromatin organization andhistone methylation), protein modifications (e.g., peptidyl-lysinemodification), and development (e.g., forebrain development and Wnt signaling).These defects not only can contribute to neurocognitive problems but also areconsistent with the broad presentation of phenotypes in CdLS.