Interestingly, variations in serpin peptidase inhibitor clade A member 6 (Serpina6), another pain gene with pronounced age differences and sex-opposite expression, are also associated with the HPA stress axis impacting the susceptibility to musculoskeletal pain (Holliday et al., 2010), the risk of cardiovascular disease, as well as gene expression in peripheral tissues (Crawford et al., 2021). This evidence concerns the gene SERPINA6 and cardiovascular disorder.