Evidence suggests that chronic hyperglycemia in patients with DM causes the body to form a self‐protection mechanism, preferentially down‐regulating glucose transporters (GLUT‐1 and GLUT‐3), allowing glucose to enter cells independently of insulin, thus reducing the acute fluctuation of glucose concentration and reducing endothelial cell apoptosis.62 This evidence concerns the gene SLC2A3 and Hyperglycemia.