The high expression of VCAM-1 and TNF-α in GDM placentas may be related to the disorder of placental vascular endothelial cells, and the increased expression of VEGF-A may be closely related to hyperplastic pathological neovascularization in placentas, which is consistent with the morphological changes of placentas in this study. The gene discussed is TNF; the disease is gestational diabetes.