AQP8 and gestational diabetes: To determine whether AQP8 affects the pathological changes of placental vascular endothelial cells and even placental vessels in GDM, HUVECs were stimulated by high glucose, and the results showed that the expression of AQP8 significantly increased after HUVECs were injured by high glucose, which indicated that AQP8 might participate in the dysfunction of HUVECs through the regulation of related signaling pathways, and then change the vascular structure of GDM placentas.