ROS have numerous downstream signaling factors, among which NF-κB is a dominant transcription factor in the cellular inflammatory response directly involved in the inflammatory response of tissues, while inducing multiple proinflammatory cytokines, including TNF, and the transcription of IL-1 and IL-6, playing a key role in the autoimmune disease process [36,37]. The gene discussed is NFKB1; the disease is autoimmune disease.