Under hyperglycemia and hyperlipidemia, HMGB1 is released from the cell nucleus and interacts with its receptors TLR2 and TLR4 on tubular cells, triggering an inflammatory response by activating the NF-κB signaling pathway to induce the production of proinflammatory cytokines [11]. The gene discussed is NFKB1; the disease is Hyperglycemia.