Although the HMGB1 interaction with TLRs via stimulation of the NF-kB pathway has been analyzed in several mouse models of DKD, the correlation between HMGB1 level and the progression of renal fibrosis is not well known [15,16,17] which slows the process of research on targeting HMGB1 for DKD therapy. The gene discussed is NFKB1; the disease is diabetic kidney disease.