HPP was clinically diagnosed by a repeat low alkaline phosphatase level of 23 U/L and high vitamin B6 level of 24.4 ng/mL (reference, 2.1-21.7 ng/mL), despite the absence of the <i>ALPL</i> gene sequence variation on genetic testing.<h4>Discussion</h4>Remarkable personal and family history of this patient suggest that co-occurrence of EDS and HPP is not merely coincidental. The gene discussed is ALPL; the disease is hypophosphatasia.