Looking for both prognostic biomarkers as well as for innovative immunomodulatory tools, here we deeply reviewed the role of LAV-BPIFB4 in positively influencing the activity of immune cells in atherosclerosis, diabetic cardiomyopathy, and cardiovascular complications to prolonged or aberrant infections (as summarized in Table 1). The gene discussed is BPIFB4; the disease is infection.