BPIFB4 and diabetic cardiomyopathy: Looking for both prognostic biomarkers as well as for innovative immunomodulatory tools, here we deeply reviewed the role of LAV-BPIFB4 in positively influencing the activity of immune cells in atherosclerosis, diabetic cardiomyopathy, and cardiovascular complications to prolonged or aberrant infections (as summarized in Table 1).