A number of DNA methylation biomarkers, including ZNF677, FBN2, PCDH8, TFAP2B, TAC1, and FLRT2, were found in kidney tissue and urine samples from patients with ccRCC and provided significant clinical assistance and promising power that does not exist in detection and prediction of invading ccRCC [100, 101]. This evidence concerns the gene ZNF677 and nonpapillary renal cell carcinoma.