A number of DNA methylation biomarkers, including ZNF677, FBN2, PCDH8, TFAP2B, TAC1, and FLRT2, were found in kidney tissue and urine samples from patients with ccRCC and provided significant clinical assistance and promising power that does not exist in detection and prediction of invading ccRCC [100, 101]. The gene discussed is TFAP2B; the disease is nonpapillary renal cell carcinoma.