CPSF3 and hepatocellular carcinoma: The formation of the HDE–U7 duplex with the pre-assembled U7 snRNP/HCC/FLASH (FLASH=FLICE-associated huge protein) complex in the histone locus bodies (HLBs) during the S phase, and its interaction with the N-terminal domain of SYMPK and CPSF100, have been proposed to trigger structural rearrangements within the HCC module needed for the activation of mRNA processing by CPSF73 (19,22–24).