In neurons of the DG, 12 out of the top 33 AD GWAS risk loci were hypomethylated with increasing amyloid plaque burden (SPI1 logFC = 0.53, WNT3 logFC = 0.64, CLNK logFC = 0.37, CLU logFC = 0.46, UNC5CL logFC = 0.31, BIN1 logFC = 0.36, SORL1 logFC = 0.37, IL34 logFC = 0.52, ACE logFC = 0.45, INPP5D logFC = 0.59, PLCG2 logFC = 0.49, CD2AP logFC = 0.27; FDR p < 0.05). This evidence concerns the gene SPI1 and Alzheimer disease.