Although not amongst the top 20 DMPTs, we found two more genes that are involved in CME to be significantly (FDR p < 0.05) hypomethylated with increasing amyloid burden: BIN1 and CD2AP. These genes were previously found to be associated with AD in both epigenome and genome wide association studies [2, 72–75]. Here, BIN1 is linked to Alzheimer disease.