The top 20 DMPTs (based on log fold change (logFC)) found in the DG included several genomic regions that are known to be altered in AD [55–58] like presenilin enhancer 2 (PEN-2, logFC =  − 0.80, FDR p = 0.001), solute carrier family 22 member 6 (SLC22A6, logFC = -0.94, FDR p < 0.001), lipopolysaccharide binding protein (LBP, logFC =  − 0.81, FDR p < 0.001), and S100 calcium binding protein A13 (S100A13, logFC =  − 0.81, FDR p < 0.001). Here, PSENEN is linked to Alzheimer disease.