The term of CD molecules is the major enriched gene family for NC-DMGs, whereas NKL subclass (Fig. 2F; Additional file 1: Table S7), HOXL subclass, and Zinc fingers C2H2-type are the 3 top-ranked enriched families for ESCC-DMGs (Fig. 2G; Additional file 1: Table S8). The gene discussed is GLIS2; the disease is esophageal squamous cell carcinoma.