At present, numerous studies are concerned with the association of PNPLA3 gene polymorphisms with non-alcoholic fatty liver disease (NAFLD) [10–12], alcoholic liver disease (ALD) [13], liver fibrosis (LF) [14, 15], and liver cirrhosis (LC) [16]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.