CLU and Alzheimer disease: Importantly, oligodendrocyte dysregulation appears to be a shared feature in both familial and LOAD, as Brase et al. found a higher proportion of an oligodendrocyte subcluster enriched for spliceosome genes highly correlated with the LOAD GWAS hits CLU, MAP1B, and PICALM in carriers of autosomal-dominant AD risk genes APP and PSEN1 [48].