Mutations in TP53, PKD1, THADA, RB1 (single copy deletion), KRAS, PIK3CA, EGFR, NF1, PTCH1, BRCA1, BRAF, ARID1A, mTOR, MET, CREBBP, ARID2, ALK, CDK12 and EMLA4-ALK (fusion) were frequent in the tumor specimens obtained from 36 PSC patients. This evidence concerns the gene RB1 and neoplasm.