Another locus with the opposite directions of allelic effects between BD and intelligence was in the gene ADCY2 (rs17826816, conjFDR = 1.04×10−4), and its G-allele was linked to higher risk of BD (OR = 1.065, P = 1.32×10−8) but lower IQ scores (beta = −0.018, P = 1.68×10−8) (Fig. S2). Here, ADCY2 is linked to Behcet disease.