A Venn diagram was drawn for 302 GRGs and 2483 IRGs, 22 candidate genes (MET, GPI, SDC2, PPARG, PSMC4, PPIA, VEGFA, ANGPTL4, SOD1, SDC1, HSPA5, ISG20, TGFA, MIF, ECD, ARTN) were obtained as shown in Fig. 1A. Twenty-two (22) IGRGs were differentially analyzed between tumor and normal tissues, among them, 16 genes showed differential expression, with SDC2 and PPARG significantly down-regulated in tumor samples. This evidence concerns the gene HSPA5 and neoplasm.