In a 2020 study, the lncMIR4435-2HG/miR-513a-5p/KLF6 axis was studied, which up-regulated clear cell renal cell carcinoma KLF6, proven to be a typical inhibitor of various localized tumours, including prostate and colorectal [50–54]. This evidence concerns the gene KLF6 and clear cell renal carcinoma.