The combined effects of high TRPM2 expression on increasing migration and invasion, shown here, as well as enhancing cell survival through maintenance of mitochondrial function, cellular bioenergetics, antioxidant response, DNA repair and promotion of cell cycle progression, shown previously, strongly support the targeting of TRPM2 in neuroblastoma and in a number of cancers, which would impact proliferation, survival, and metastasis. This evidence concerns the gene TRPM2 and cancer.