Since ATL is a neoplasm of CD4+ T lymphocytes, and both CARD11(E626K) and HBZ were expressed in CD4+ T cells in our mice, we next evaluated the absolute numbers of CD4+ T cells and their subsets, namely CD4+CD44+CD62L− Tem and CD4+CD25+ Treg, together with CD8+ T cells, in the body of each mouse as the sum of their numbers in the whole bone marrow and whole spleen20,21 (Fig. 5, Supplementary Fig. 4). This evidence concerns the gene CD8A and neoplasm.