SST and Anxiety: A causal link between dysfunction of SOM cells and stress-related neuropsychiatric disorders has been previously hypothesized based on rodent studies showing that: (1) chronic stress induces low RNA levels of somatostatin in corticolimbic regions67; (2) brain-wide silencing of SOM cells elevates anxiety-like behaviors68; and (3) brain wide disinhibition of SOM cells through genetic inactivation of GABAA receptors has antidepressant-like effects68.