A recent study has illustrated that YTH domain-containing protein 1 (YTHDC1) facilitates cytoplasmic transportation of circNSUN2 in an m6A methylation-dependent manner, thus stabilizing HMGA2 to promote liver metastasis in CRC [29], raising the possibility that YTHDC1 might be implicated in the cytoplasmic export of circFNDC3B in CRC cells. The gene discussed is YTHDC1; the disease is colorectal carcinoma.