APOE and Mental deterioration: Therefore, we investigated whether the recently identified independent SNPs by Davies and Lam et al. [14] along with two APOE SNPs, were associated with general cognitive functioning at baseline and general cognitive decline in the Doetinchem Cohort Study (DCS) over an extended period of time (up to 20-years follow-up) and with up to five repeated cognition measurements in older adults (n = 2559).