Furthermore, some authors have suggested that excessive leptinemia and lipocalin deficiency in viscerally obese patients may directly stimulate the renin‐angiotensin‐aldosterone system,43 which would lead to albuminuria and hypertension,43 and this could partly explain the stronger correlation between CVAI and UACR in the hypertensive population because hypertension and albuminuria might occur together in viscerally obese patients. The gene discussed is REN; the disease is Hypertension.