CHMP2B and proteostasis deficiencies: In addition, heightened TE expression occurs in the context of tauopathies (Guo et al., 2018; Sun et al., 2018) and a distinct FTD-related proteinopathy because of pathogenic CHMP2B variation (Skibinski et al., 2005; Mackenzie and Neumann, 2016; Fort-Aznar et al., 2020).