First, although we have replicated our primary RNA-seq findings—globally upregulated peripheral TE expression and upregulation of IFN-I signaling genes—in symptomatic HRE carriers in an independent cohort, the replication cohort was smaller, and therefore some findings replicated with only marginal significance (e.g., increased expression of L1HS in C9-ALS vs control PBMCs). This evidence concerns the gene C9 and amyotrophic lateral sclerosis.