Remarkably, a Drosophila model of pathogenic CHMP2B variation, which causes FTD characterized by atypical TDP-43- and tau-negative neuropathology (Skibinski et al., 2005; Mackenzie and Neumann, 2016), also involves augmented TE expression (Fort-Aznar et al., 2020), suggesting that heightened TE expression and retrotransposition may represent a general mechanism underlying multiple forms of neurodegeneration. This evidence concerns the gene MAPT and frontotemporal dementia.