Impaired degradation of a promoter of IFN signaling has been proposed (McCauley et al., 2020), but gut microbiota (Burberry et al., 2020) and heightened expression of cytoplasmic double-stranded RNA in C9-ALS/FTD brains may also be important contributors (Rodriguez et al., 2021). Here, IFNA1 is linked to amyotrophic lateral sclerosis.