Disruptions to gonadotropin secretion patterns, implying altered GnRH release, can contribute to infertility including idiopathic hypothalamic hypogonadism (Legro, 2003; Tsutsumi and Webster, 2009; Sidhoum et al., 2014) and polycystic ovary syndrome (PCOS; Legro, 2003; Burt Solorzano et al., 2012). The gene discussed is GNRH1; the disease is polycystic ovary syndrome.