PRL and mastodynia: The findings of the study showed a decrease in prolactin levels, normalization of shortened luteal phases duration, and elimination of luteal progesterone.55Estimated high to moderate heterogeneity was observed between studies in the evening primrose and Vitex-agnus-castus subgroups, which may be related to different amounts of effective ingredients, different ages of the participants, and different mastalgia severity and pattern of (cyclical and noncyclical).