Our research team was successful in using linkage analysis and candidate gene sequencing to identify HOXB13 as a prostate cancer susceptibility gene.10 A recurrent nonsynonymous change was identified, which results in the nonconservative substitution of glutamic acid for glycine (G84E), in probands from four unrelated prostate cancer families. The gene discussed is HOXB13; the disease is Familial prostate cancer.