Importantly, defects in this gene are associated with Lynch syndrome or hereditary nonpolyposis colorectal cancer,55 and potentiate the formation of supratentorial primitive neuroectodermal tumors.56 Consequently, the potential relevance of PMS2 genetic variation in prostate cancer development appears logical and may be worth analyzing in future sequencing studies. The gene discussed is PMS2; the disease is Familial prostate cancer.