BRCA1 and Werner syndrome: Although WRN is typically associated with the phenotypic effects in Werner's syndrome, an analysis of a patient with a family history of prostate cancer by next-generation sequencing identified heterozygosity for the WRN G327X variant.54 The WRN protein, along with ATM, BRCA1, BRCA2, and RAD51 among others, comprises a DNA repair system by homologous recombination, indicating that its alterations may increase susceptibility to prostate cancer.