KLK3 and Familial prostate cancer: This variant is almost exclusively observed among men of European ancestry, with variable risk estimates.40 The G84E variant is more common among men with a strong family history of prostate cancer and those diagnosed at younger ages.13 Furthermore, Storebjerg et al41 demonstrated that the variant is more frequently observed in men with a higher PSA at diagnosis, higher Gleason score, and higher likelihood of positive surgical margins at the time of radical prostatectomy than noncarriers, indicating that this genetic variant may also be associated with aggressive disease.