Therefore, the baseline analysis of BRIGHTEN has investigated the contributing factors for initial responsiveness to ESA and reported that non-responders to DA accounted for 13.3% of patients with ND-CKD, whereas iron supplementation, low CRP, low NT-proBNP, and less proteinuria were predictive and modifiable factors associated with a better initial response to DA [24]. This evidence concerns the gene NPPB and chronic kidney disease.