Of note, compared with recipients deficient in IFN-γR expression only in nonhematopoietic tissue, GVHD-induced mortality was further enhanced when both hematopoietic and nonhematopoietic tissues (BALB/c→(B6.Ifngr1–/–→Β6.Ifngr1–/–) lacked IFN-γR (Figure 2F). Here, IFNGR1 is linked to graft versus host disease.