In an attempt to embrace all of the data collected in this study, variants were ranked according to a CES that factored in the level of recombinant protein production as well as the results of all five functional assays (see Materials and Methods), and these scores were plotted (Fig. 7A) along with their AMD-risk odds ratios, and they are represented schematically in a structural context in Figure 7B. A summary of CES data for all variants in the context of their locations within the FH structure is presented in Supplementary Figure S8. The gene discussed is FH; the disease is age-related macular degeneration.