CD74 and autoimmune disease: In a mouse model of experimental ischaemia-reperfusion injury, renal tubular injury was more severe in MIF, MIF-2 and CD74 knockout mice than in wild-type control mice(Ochi et al., 2017), and the autoimmune disease systemic lupus erythematosus (SLE) can cause renal inflammation known as lupus nephritis (Almaani et al. 2017).