The downregulated genes on day 7 Fos, Hspa1a, Hspa1b, and Jun were enriched in the Estrogen signalling pathway, measles, MAPK signalling pathway, lipid and atherosclerosis, prion disease, human T-cell leukaemia virus 1 infection, endocrine resistance, and antigen processing and presentation (Supplementary 11). The gene discussed is JUN; the disease is prion disease.