Therefore, our results support other studies showing the beneficial effects of β3AR overexpression [6, 18, 27], and emphasize the need for current interventional trials to probe clinical benefits and mechanistically explore the advantageous effects of β3AR stimulation against adverse myocardial remodeling in HF [3, 60], so as to overcome limitations of previous ones [9]. The gene discussed is ADRB3; the disease is hydrops fetalis.