PTGS2 and cancer: The same dose (200 mg/kg) of EBPS showed a therapeutic and protective effect on chemically induced mammary carcinomas through (i) decreasing cancer growth rate-limiting enzymes (aromatase and Na+/K+ATPase), (ii) modulating female sex hormones (estrogen and progesterone), (iii) alleviating oxidative stress, and (iv) suppressing COX-2 production.