PTGS2 and Familial prostate cancer: Case of inflammation appeared concurrently with prostate cancer induction, where cancer group rats produced more COX-2 (0.213 ± 0.01 ng/mL with 23.84%) and less COX-1 (0.375 ± 0.02 μg Eq/mL, with 29.25%), compared to the negative control (Fig. 4).