In addition, it has been shown that EPB41L3 can also inhibit cell growth by inducing apoptosis and cell cycle arrest. Positive correlation between PDIA5 and immune infiltrating cells, immune related pathways, inflammatory activities, and other immune checkpoint members in gliomas [25]. And our study demonstrates that PDIA5 was associated with neutrophil degranulation, activation of neutrophils involved in immune response, mitosis, regulation of cell cycle phase transition, and ATPase activity in UC. The gene discussed is PDIA5; the disease is central nervous system cancer.