Out of the five remaining candidates that were tested for segregation in the extended family, two variants segregated with the severe HL in an autosomal recessive (NM_016252.3:c.2448G > C, p.E816D in BIRC6, encoding Baculoviral IAP Repeat Containing 6) and an autosomal recessive or semi-dominant manner (NM_001261826.3:c.2131G > A, p.V711I in AP3D1), respectively (Table 3). The gene discussed is BIRC6; the disease is Hodgkins lymphoma.