CXCL10 and viral infectious disease: Given our findings above and the supportive data in the literature, we hypothesize that V937 viral infection leads interferon-gamma–mediated secretion of CXCL10 by multiple cell types in the tumor microenvironment, especially macrophages [24], which promotes response to anti–PD-1 therapy through improving local guidance of activated lymphocytes to the dendritic cells [22].