PBK and neoplasm: NanoString analysis demonstrated significantly higher expression in pretreatment tumor samples from responders versus nonresponders of 3 genes (CD3e molecule, epsilon associated protein [CD3EAP], interferon-induced protein with tetratricopeptide repeats 2 [IFIT2], and PDZ-binding kinase [PBK]) and lower expression of 35 genes (all P < 0.05; Fig. 2a).