PANK2 and Parkinson disease: The neuronal firing patterns observed in PANK2, which are more similar to those seen in Parkinson’s disease, are in turn in keeping with the clinical phenotype.41,42 However, since the basal ganglia, thalamic and brainstem resting glucose metabolism in PANK2 is similar to controls (Table 2), the pathological focus for an anatomical ‘source’ and ‘mechanism’ of dystonia in PANK2 could plausibly fall to the bilateral cerebellar dentate nucleus hypometabolism.