Additionally, the phosphatidyl inositol 3-kinase(PI3K)/Akt signalingpathway is the main prosurvival pathway implicated in prostate cancerprogression and the development of castration resistance.37 Moreover, it has been demonstrated that thePI3K/Akt signaling pathway is involved in the resistance responseto hypoxia and regulates the expression of HIF-1α.38 To further investigate the effect of dendrimerson prostate cancer cells, the PI3K/Akt signaling pathway was examinedin this study. This evidence concerns the gene HIF1A and prostate cancer.