HIF-1α activity was significantly reduced by G2Ru and G2P dendritic systems, which allow a significantdecrease on VEGF expression, a specific HIF-1α regulated gene.Therefore, the HIF-1α targeting capacity of both dendrimerswould trigger the reduction of vascularity in the area surroundingthe tumor by the inhibition of angiogenesis induction. The gene discussed is VEGFA; the disease is neoplasm.