Herein, we have completed a thorough study tobetter understand the effect within the cell of the already publishedruthenium(II)-N-heterocyclic carbene metallodendrimer (G2Ru) that was able to drastically reduce HIF-1α stabilizationand exhibited antiproliferative capability against androgen-sensitive(LNCaP) and androgen-resistant prostate cancer cells (LNFLU) in vitro. Here, HIF1A is linked to prostate carcinoma.