G2Ru and G2P effects were studiedon a sensitive prostate cancer cell line (LNCaP) and on an in vitro-generated resistant prostate cancer cell line (LNFLU)which exhibited resistance to Flutamide and Docetaxel, commonly usedin clinic as prostate cancer chemotherapeutics.26 Thereby, in the current study, we expose the results of in vitro analysis related with the anticancer potentialof these dendrimers and their HIF-1 targeting effect. This evidence concerns the gene HIF1A and Familial prostate cancer.