It is worth mentioning that the IC50 values weresignificantly lower than those found with commonly PCa chemotherapeuticagents such as Flutamide or Docetaxel.26 In addition, both dendrimers inhibited the PI3K/Akt/mTOR signalingpathway, a survival mechanism essential to the normal cellular functionand commonly source of function mutated in cancer models. This evidence concerns the gene AKT1 and posterior cortical atrophy.