Some of these mechanisms go from the suppression of proapoptoticfactors to the activation of growth factors and prosurvival proteinstriggering the singular aberrant proliferation ability of cancer cells.39,40 Thereby, to determine whether the metallodendrimer or its precursordendrimer would be able to promote apoptosis in the prostate cancercell lines, Annexin V and propidium iodide labeling of cells was conducted.Treatment of the androgen-sensitive LNCaP cell line with the dendrimersresulted in a significant increase in the percentage of late apoptoticcells (Figure 7). The gene discussed is ANXA5; the disease is cancer.