Moreover,preliminary results show that both dendrimers were able to reduceVEGF expression even in the presence of cobalt chloride (II), a well-knowninhibitor of HIF-1α proteasomal degradation (Supporting Information Figure S3), suggesting a potent effectof G2Ru and G2P.35 Therefore, the scavenging ability of both dendritic systems couldbe blocking the adaptation of these PCa cell lines to hypoxia, hinderingHIF-1α stabilization by the ROS decrease and thus preventingVEGF expression. This evidence concerns the gene HIF1A and posterior cortical atrophy.