Based on 9 ERSRGs (AQP11, BCL2, EDEM2, EXOSC7, FLOT1, PPP1R1B, PPP1R8, TXNIP, WFS1), we successfully constructed a prognostic risk model that precisely estimate the prognosis of COAD patients. The gene discussed is EDEM2; the disease is colon adenocarcinoma.