During an HCMV infection, endogenous MHC II expression is downregulated (60), IFN-γ dependent inducible expression of MHC II is inhibited (61), the assembly of the peptide-MHC II complex is blocked (62), the localization of MHC II is disrupted (63), and the complex is targeted for degradation (64). This evidence concerns the gene IFNG and cytomegalovirus infection.