Notably, the heterogeneity of TMEM173 (STING) gene is observed in different ethnic populations‐ for example, HAQ (R71H‐G230A‐R293Q) is dominant in East Asian, while Africans have no HAQ.[69] If these various STING variants affect STING binding with VDAC2 and determine STING dependency for cell growth in cancers beyond RCC warrants further in‐depth investigations. The gene discussed is VDAC2; the disease is cancer.