Activating STING has been shown to improve therapeutic effects of immune‐checkpoint blockades.[24] STING also exerts a protective effect in metabolic diseases such as alcoholic liver disease,[25] cardiovascular diseases including myocardial infarction,[26] aging,[27] and others[28] through promoting IRF3 phosphorylation and activation of innate immune signaling. Here, STING1 is linked to metabolic disease.