Other than nucleotide sensing, hyperactivation of STING has been observed and connected with inflammatory diseases from both pathological perspectives (for example, STING‐associated vasculopathy with onset in infancy (SAVI) disease is caused by GOF mutations in STING[18]) and genetic animal models (for example, systemic lupus erythematosus symptom can be largely rescued in STING‐deficient mice[19]). This evidence concerns the gene STING1 and vascular disorder.