We reconstituted STING‐depleted A498 cells with WT‐STING or the STING‐CACA mutant (Figure 3S) and found that only the WT‐STING partially rescued A498 cell growth in vitro (Figure 3T–U), further indicating that the STING‐VDAC2 interaction in the mitochondria is critical in suppressing VDAC2 functions and promoting RCC cell growth. Here, VDAC2 is linked to renal cell carcinoma.