CGAS and kidney cancer: A recent study profiling cGAS/STING expression in human tumors confirmed reduced STING expression in most cancer types, but a few tumors including kidney cancer (KIRC) showed STING overexpression.[33] Our analyses of the TCGA dataset identified gene amplification of STING (TMEM173, STING1) but not cGAS (MB21D1) (Figure 1A), as well as increased STING mRNA levels (≈10%) in clear cell renal cell carcinoma (ccRCC) (Figure 1B).