Notably, the heterogeneity of TMEM173 (STING) gene is observed in different ethnic populations‐ for example, HAQ (R71H‐G230A‐R293Q) is dominant in East Asian, while Africans have no HAQ.[69] If these various STING variants affect STING binding with VDAC2 and determine STING dependency for cell growth in cancers beyond RCC warrants further in‐depth investigations. This evidence concerns the gene VDAC2 and renal cell carcinoma.