To further examine a possible innate immunity‐independent function of STING in governing RCC growth, we depleted cGAS, the upstream activator of STING in cytosolic DNA sensing, in either A498 or RCC10 cells by shRNAs (Figure S2A, Supporting Information) or sgRNAs (Figure S2B,C, Supporting Information). The gene discussed is STING1; the disease is renal cell carcinoma.