TNF and rheumatoid arthritis: In a retrospective cohort study, there was no HBr in 178 patients treated with anti-TNF agents.13 Also, in another retrospective cohort study, HBr was seen in 0.9% of IMID patients exposed to anti-TNF agents.14 In patients with RA, HBr was found to be 1.1% in patients exposed to anti-TNF agents and 5.5% in all biologic treatments including anti-TNF agents.15 Also, in another RA cohort, HBr was found to be 3.1% in patients who were exposed to anti-TNF agents and 5.2% in all biologic treatments including anti-TNF agents.