MAPT and Alzheimer disease: There is accumulating evidence that Aβand Tau proteins may act synergistically to cause synaptic dysfunction,neurofibrillary tangle-mediated neuronal loss, and behavioral deficits.A recent publication has shed light on how Aβ and Tau mightcooperate in causing AD phenotypes.6 Aβseems to initiate the neuroinflammation process, making synapses vulnerableto Tau-associated molecular changes, such as the loss of synapticproteins.