Notably, although Orho‐Melander et al. found no significant associations with the identified SNPs in the genetic scores for HDL‐C or LDL‐C, they found a significant decrease in the odds of breast cancer for each copy of HMGCR rs12916 allele, which mimics the effect of statins (OR [95% CI]: 0.89 [0.82–0.96] per LDL‐lowering T‐allele).49 This evidence concerns the gene HMGCR and breast cancer.