Tortora et al.69in their recent study demonstrated that the administration of JWH‐133 [100 nM] as an agonist of cannabinoid receptor 2 (CB2), a receptor with important anti‐inflammatory and immunoregulatory properties that affects immune cells activation, induced CD patients' peripheral blood isolated MQs polarization toward the anti‐inflammatory M2 phenotype.69 This evidence concerns the gene CNR2 and Cowden disease.