The SLE patients had higher Th1/Treg (p < .001), Th17/Treg (p = .001), T/Treg (p = .025), and B/Treg (p < .001) ratios and lower CD4+ T/CD8+ T (p < .001) and NK/Treg (p = .005) ratios than the HCs. Here, CD8A is linked to systemic lupus erythematosus.